The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis*210

HIGHLIGHTS

• who: Howard N. Hunter from the cally labeled amino acids, Ile, Phe, and, Gly were used in the Fmoc (N-(9-fluorenyl)methoxycarbonyl) processBoth isotopic forms of the refolded synthetic hepcidin had the predicted masses by spectrometry, and, when compared with the natural hepcidin (20- and, amino acid forms) isolated from urine (1), migrated identically in, .5% acidurea PAGE and had an identical retention time on , reverse phase high precision liquid chromatography. NMR Spectroscopy-Approximately , mg of the, amino acid peptide was dissolved in , ␮l of, :, H O:D O. The unadjusted pH was, .2, and the . . .
  

   

  

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