The spectraplakin dystonin antagonizes yap activity and suppresses tumourigenesis

HIGHLIGHTS

• who: Praachi B. Jain from the InstitutUniversidade have published the research work: The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis, in the Journal: Scientific Reports Scientific Reports
• what: The authors provide a molecular mechanism for the tumour-suppressing function of DST. The authors show that DST prevents Zyxin accumulation in MCF10A cells.
• how: MCF10A-ER-Src cells treated with TAM or with the vehicle EtOH were tested for DST mRNA levels at different time during the 36 hours of treatments (see experimental design in Fig 1A) using primers amplifying all DST isoforms . . .
  

   

  

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