The spectrum of tuberculosis described as differential dna methylation patterns in alveolar macrophages and alveolar t cells

HIGHLIGHTS

SUMMARY

The authors performed this study to evaluate if alveolar macrophages and alveolar T_cells exposed to M. tuberculosis undergo epigenetic reprogramming, reflected as differentiated DNA methylation (DNAm) patterns in individuals exposed to the pathogen. Alveolar macrophages and alveolar T_cells were procured via induced sputum, which has been verified as an equivalent method to bronchoalveolar lavage for the seclusion of the two cell types, and isolated in accordance with a wellestablished method. Analyses of the DNA methylomes of the isolated alveolar macrophages and alveolar T_cells allowed the authors to identify distinct DNAm signatures in patients with . . .

 



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