The spoc domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

HIGHLIGHTS

• who: Lisa-Marie Appel from the (UNIVERSITY) have published the research: The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators, in the Journal: (JOURNAL) of 26/02/2022
• what: The authors report the crystal_structure of SHARP SPOC in complex with CTD and identify the molecular determinants for its specific binding to phosphorylated serine-5. This analysis showed SPOC-dependent interaction of SHARP with FMR1, FXR1, and FXR2, which was confirmed for FMR1 by Western blotting (Fig 5d and Supplementary Data 2). The authors show that SHARP . . .
  

   

  

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