The staphylococcus aureus protein isdh inhibits host hemoglobin scavenging to promote heme acquisition by the pathogen*

HIGHLIGHTS

• who: Kirstine Lindhardt Sæderup from the (UNIVERSITY) have published the article: The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen*, in the Journal: (JOURNAL) of November/11,/2016
• what: The authors show that IsdH only binds Hb-Hp via a direct Hb interaction without direct contact to the Hp subunit, in contrast to previous reporting of a direct low affinity interaction between IsdH and Hp. This study shows that S. aureus IsdH blocks the CD163-mediated uptake of Hb-Hp complexes, which instantly form when Hb is . . .
  

   

  

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