The stem cell regulator pedf is dispensable for maintenance and function of hematopoietic stem cells

HIGHLIGHTS

• who: Emma Ramp#x000F6 and rby from the important role in fine-tuning HSC properties and fateInterestingly, PEDF have been shown to be expressed at highest levels in murine HSCs (https://gexc.riken.jp/models/3/genes/Serpinf1?q=serpinf1) based on The Gene Expression Commons, Stanford University in which microarray expression profiles of immature and mature hematopoietic subsets can be visualized18. Furthermore, another study showed that PEDF expression levels in FDCP-mix cells are downregulated upon differentiation19. Together, these results indicate that PEDF expression is important in primitive HSCs and that it declines as HSCs undergo . . .
  

   

  

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