The store-operated ca2+ channel orai1α is required for agonist-evoked nf-κb activation by a mechanism dependent on pkcβ2

HIGHLIGHTS

• who: Joel Nieto-Felipe from the Department of Physiology (Cellular Physiology Research Group), Institute of Molecular (IMPB), University of Extremadura, Caceres, Spain have published the research work: The store-operated Ca2+ channel Orai1u03b1 is required for agonist-evoked NF-u03baB activation by a mechanism dependent on PKCu03b22, in the Journal: (JOURNAL)
• what: Using a combination of biochemistry and imaging combined with the use of HEK293 knockout cells missing the native transfected with plasmids encoding for either Orai1uf061 or Orai1uf062 the authors show that Orai1u03b1 plays a relevant role agonist-induced transcriptional activity. contrast functional Orai1u03b2 . . .
  

   

  

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