The strange case: the unsymmetric cisplatin-based pt(iv) prodrug [pt(ch coo)cl (nh ) (oh)] exhibits higher cytotoxic activity with respect to its symmetric congeners due to carrier- mediated cellular uptake

HIGHLIGHTS

• who: Elisabetta Gabano and colleagues from the Vercelli, Italy have published the Article: The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH COO)Cl (NH ) (OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier- Mediated Cellular Uptake, in the Journal: Bioinorganic Chemistry and Applications 2.5 of 30/Dec/2022
• what: Te IC50 data of 2 on all the cell lines employed represent an anomaly if the authors reason in terms of passive difusion only, which is modulated by lipophilicity.
• how: In each experiment cells . . .
  

   

  

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