HIGHLIGHTS
- who: Rita Moreno from the Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK have published the research: The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress, in the Journal: (JOURNAL)
- what: The authors demonstrate that in triple-negative breast cancer (TNBC) cells the dual specificity tyrosine-regulated kinase 2 (DYRK2) phosphorylates HSF1 promoting its nuclear stability and transcriptional activity. By interrogating publicly available datasets, the authors show that, as recently reported , DYRK2 mRNA levels are often higher in tumour than in normal tissue, correlating . . .
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