The structural basis for mrna recognition and cleavage by the ribosome-dependent endonuclease rele

HIGHLIGHTS

• who: Cajetan Neubauer and colleagues from the Laboratory of Molecular Biology, Cambridge , QH, UK Aarhus University have published the article: The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE, in the Journal: (JOURNAL) of December/11,/2009
• what: The authors propose that the high local concentration of positive charges in the active_site lowers the pKa of Y87 by stabilizing the negatively charged, deprotonated form.
• how: The untagged form of RelE crystal- lized in the monoclinic space group P1211 and diffraction data were collected to 2.5 Å.
 



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