The structural basis for optimal performance of oligothiophenebased fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates

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  • who: FULL PAPER from the (UNIVERSITY) have published the Article: The Structural Basis for Optimal Performance of OligothiopheneBased Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates, in the Journal: (JOURNAL)
  • what: The authors report the synthesis of a set of novel thiophenebased amyloid ligands designed with minor variations in the chemical structure to restrict or increase the conformational flexibility of the conjugated backbone.
  • how: The results from this study identified conformational freedom and extended conjugation of the conjugated backbone as crucial determinants for obtaining superior . . .

     

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