The structure of the human lactb filament reveals the mechanisms of assembly and membrane binding

HIGHLIGHTS

  • who: Jeremy A. Bennett and collaborators from the Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, United States of America have published the research work: The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding, in the Journal: (JOURNAL) of December/19,/2022
  • what: The authors describe how human LACTB self-assembles into micron-scale filaments that increase their catalytic activity. The authors provide supporting biochemical analysis of the assembly, where structureguided mutations at different filament-forming interfaces unveil that polymerization is essential for the catalytic activity of LACTB . . .

     

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