HIGHLIGHTS
- who: Clara Ballerini from the (INGM), Italy, (NEUROFARBA), University of Florence have published the article: The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies, in the Journal: (JOURNAL) of September/29,/2018
- what: The authors focused on changes of 1 a.a. as they may reflect clones with similar antigen-binding profile . The work demonstrates that investigating MS patient TCR repertoires during immunomodulatory treatments by deep sequencing methodologies applied on T-cell subpopulations and followed by rigorous statistical analysis enables to distinguish the different treatment effects on immune_response and suggests . . .
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