The tnfr1 antagonist atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

HIGHLIGHTS

• who: Natalia Ortu00ed-Casau00f1 from the DepartmentUniversity of have published the Article: The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration, in the Journal: Scientific Reports Scientific Reports
• what: The authors aimed to validate the novel monovalent TNFR1 antagonist u00adAtrosimab25,26 in a NMDA-induced acute neurodegeneration mouse model. For the IBA-1 immunohistochemistry, the authors aimed at determining total lesion volume and, thus, 7 serial sections per brain were selected.
• how: For CD68 and GFAP the authors investigated specific inflammatory responses after . . .
  

   

  

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