The topography of transmembrane segment six is altered during the catalytic cycle of p-glycoprotein*

HIGHLIGHTS

• who: Alice Rothnie from the ‡Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UH, United Kingdom have published the research work: The Topography of Transmembrane Segment Six Is Altered during the Catalytic Cycle of P-glycoprotein*, in the Journal: (JOURNAL) of May/13,/2004
• what: The topography of TM6 of the model is in good agreement with the data presented in the current investigation, and the model was subsequently used to infer the structural changes accompanying nucleotide binding.
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