The transcription factor foxp3 can fold into two dimerization states with divergent implications for regulatory t cell function and immune homeostasis

HIGHLIGHTS

• who: Fangwei Leng from the Hughes Medical Institute, Boston, MA, USA Tong University have published the research: The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory Tu00a0cell function and immune homeostasis, in the Journal: (JOURNAL)
• what: The authors propose an overall architecture of FoxP3-DNA complex, where the H-H dimer of FoxP3RBR-forkhead forms the primary contact with DNA, whereas two ZFs flexibly tethered through CC and RBR form secondary contacts with nearby sites on DNA without a fixed location relative to FoxP3RBR-forkhead .
• how: The . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.