The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by erk1/2

HIGHLIGHTS

• who: Borb#_#x00E1 and collaborators from the of the University of Debrecen, Medical Faculty, in, University of Angers, Angers, France have published the research: The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0172020]. February 14, 2017 of /1371/
• what: The authors show that ERK1/2 is capable of directly phosphorylating HNF4α in vitro at several phosphorylation sites including residues previously shown to be targeted by other kinases as well. In the model system, HNF4α was introduced . . .
  

   

  

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