HIGHLIGHTS
SUMMARY
Many functions have been attributed to for these clusters, such as transcriptional coordination among different genomic loci, enhancement of gene_expression efficiency, 3D genome organization, and facilitation of chromosome translocation in cancers6-10. The authors first examined and ensured that the GFP and degron tags did not affect RUVBL2 ChIPSeq signals or gene_expression compared with those in wild-type mESCs (Supplementary Fig 2a-c). The signals emitted by the recruited protein also varied among cells, possibly because of stochastic gene_expression or variations in transfection efficiency (Fig 4b). The results showed that RUVBL1 and RUVBL2 were . . .
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