The tumor suppressor pten negatively regulates insulin signaling in 3t3-l1 adipocytes*

HIGHLIGHTS

  • who: Naoki Nakashima from the (UNIVERSITY) have published the Article: The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes*, in the Journal: (JOURNAL) of December/15,/1999
  • what: The authors examined the effects of PTEN on insulin signaling using an adenovirus (Ad-PTEN) engineered to express PTEN in differentiated 3T3-L1 adipocytes.
  • how: To explore this question the authors examined the effects of PTEN on the activity or phosphorylation status of various intermediates in the insulin signaling pathway.

SUMMARY

    PTEN is capable of dephosphorylating phosphatidylinositol 3 . . .

     

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