The two faces of dna oxidation in genomic and functional mosaicism during aging in human neurons

HIGHLIGHTS

• who: October and collaborators from the University of Rochester, United States have published the paper: The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons, in the Journal: (JOURNAL)
• what: Data from CS/XP mouse models and human patients suggest that unrepaired DNA damage accumulates in these diseases and causes cell death via transcriptional dysregulation (de Vries et_al, 1997; Giese et_al, 1999; Dolle et_al, 2006; Tiwari et_al, 2021), and the work showed that somatic mutations also increase in human CS and XP patient neurons (Lodato et_al, 2018).
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