The uas thioredoxin-like domain of ubxn7 regulates e3 ubiquitin ligase activity of rnf111/arkadia

HIGHLIGHTS

• who: Sadek Amhaz from the (UNIVERSITY) have published the research: The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia, in the Journal: (JOURNAL)
• what: The authors have identified UBXN7 as a direct regulator of RNF111. Noticeably, the authors provide evidence that, unlike RNF111, TOPORS protein level is not regulated by UBXN7 which is consistent with the observation that TOPORS does not auto-ubiquitylate and is not degraded by the proteasome, suggesting that UBXN7 might only act as an inhibitor for TOPORS function. Noteworthy, the study has assigned a function . . .
  

   

  

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