HIGHLIGHTS
- who: Kendra S. Plafker from the (UNIVERSITY) have published the article: The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2*, in the Journal: (JOURNAL) of July/23,/2010
- what: In this report, the authors demonstrate that the highly conserved metazoan E2 UbcM2 has the capacity to regulate Nrf2 function in a novel way. The authors show that the capacity of UbcM2 to stabilize the transcription factor is primarily mediated by a non-catalytic cysteine in the enzyme, takes place in the nucleus, requires an intact active_site, and . . .
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