HIGHLIGHTS
SUMMARY
To accomplish this target, the long circulating liposomes loaded with SIM and DOX (SIM-DOX-LCL) were designed for intravenous administration to increase the bioavailability of both SIM and DOX due to their intensive hepatic metabolization. As the screening study has pointed pointed out, PL, SIM and DOX concentrations, as well as the pH of the AS solution, preout, PL, SIM and DOX concentrations, as well as the pH of the AS solution, presented the sented the greatest influence on SIM-DOX-LCL CQAs. Pharmaceutical Formulation Concentration (µM) IC50 (µM) SIM DOXO T47D SIM . . .
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