The value of rare genetic variation in the prediction of common obesity in european ancestry populations

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Twin and family studies Frontiers in Endocrinology | www.frontiersin.org May 2022 | Volume 13 | Article 863893 Rare Genetic Variation and Obesity program to build obesity PRSs that use rare variants (PRSsrare) and test their associations with obesity and extreme obesity. Aggregating ultra-rare variants in genes, based on their predicted functional consequences, offers a potentially powerful complementary approach to the single variant testing and subsequently, building rare variant PRSs. The authors built and tested PRSs from common variants (MAF ≥ 1%), rare variants (MAF and amp;lt; 1%) and ultra-rare variants (MAF and amp . . .

 



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