The vegf/vegfr axis revisited: implications for cancer therapy

HIGHLIGHTS

  • who: Peace Mabeta and Vanessa Steenkamp from the Department of Physiology, Faculty of Health Sciences, University of Pretoria, Gezina, South Africa have published the research: The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy, in the Journal: (JOURNAL)
  • what: To date, several anti-angiogenics have been designed to target VEGF and its receptors for cancer treatment.
  • future: Future studies should establish whether the restoration of the VEGFxxxa/xxxb balance leads to vascular normalization which is a desirable effect to enhance drug extravasation into the tumor and thus improve the effectiveness of chemotherapy and . . .

     

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