The vital role of constitutive gpcr activity in the mesolimbic dopamine system

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  • who: F J Meye from the (UNIVERSITY) have published the Article: The vital role of constitutive GPCR activity in the mesolimbic dopamine system, in the Journal: (JOURNAL)
  • what: The aim of the current review is to describe the role that the constitutive activity of several key GPCRs has in regulating the highly therapeutically relevant midbrain dopamine system. It stands to reason that as long as the primary aim of a treatment is to reduce signaling of an endogenous ligand at its GPCR in the midbrain dopamine system, neutral antagonists will be less prone to induce . . .

     

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