The yin and yang of hsa-mir-1244 expression levels during activation of the upr control cell fate

HIGHLIGHTS

• What: The authors report the discovery that hsa-miR-1244 changes during UPR signaling fine tune this pathway to modulate cell fate decisions. Since ER stress reduced miR-1244 levels, the authors decided to include in the analysis transcripts that were identified to be upregulated during ER stress in the previous genome wide analysis in 16HBE14o- cells . The authors focused on miRNA potential targets that were important for UPR and tried to address their changes with two independent ER stress models. In this study, the goal was to understand the relationship between the UPR and downregulation of . . .
  

   

  

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