Therapeutic and prognostic potential of gpcrs in prostate cancer from multi-omics landscape

HIGHLIGHTS

SUMMARY

    2018; Wang et_al, 2019; Wu et_al, 2019; Kaushik et_al, 2020). Malignant cells use chemokine receptors to migrate to distant sites of ligand expression, for example, CCR7 and CCR10 were demonstrated to participate in metastatic homing of cancer cells and cell growth (Balkwill, 2004; O`Hayre et_al, 2008). Specifically, OR51E1 and OR51E2 were reported to suppress proliferation and promote cell death in LNCaP cells (Xu et_al, 2000; Weng et_al, 2005; Rodriguez et_al, 2014; Pronin and Slepak, 2021), thus being considered as prostate-specific GPCRs. A much higher level of GPR160 expression was observed in human . . .

     

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