Therapeutic chemical screen identifies phosphatase inhibitors to reconstitute pkb phosphorylation and cardiac contractility in ilk-deficient zebrafish

HIGHLIGHTS

• who: Alexander Pott and colleagues from the Department of Internal Medicine II, Ulm University, Albert-Einstein-Allee, Ulm, Germany have published the Article: Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish, in the Journal: (JOURNAL)
• what: Using the zebrafish as drug screening platform, the authors aimed to identify chemical compounds rescuing heart failure in msq mutant embryos via maintenance of PKB phosphorylation. Although the authors show promising results of at least two compounds for the treatment of genetic ILK-dependent cardiomyopathy in a vertebrate model, additional . . .
  

   

  

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