Therapeutic targeting of atr in alveolar rhabdomyosarcoma

HIGHLIGHTS

• who: Heathcliff Dorado Garcu00eda from the Patient-derived xenograft (PDX) treatment The establishment of PDX models was conducted as previously described, in collaboration with Experimental Pharmacology and Oncology GmbH (EPO, Berlin, Germany)Briefly, a tumor fragment was serially transplanted in mice at least three times prior to the experiments. All experiments were conducted according to the institutional animal protocols and the national laws and regulations and approved by the Charitu00e9 University Medicine and MSKCC IACUC. Fusion status was determined by PCR at time of diagnosis. Tumor fragments from rhabdomyosarcoma patients were transplanted into NOD.Cg-Prkdcscid Il2rgtm . . .
  

   

  

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