Therapeutic vs. suprapharmacological metformin concentrations: different effects on energy metabolism and mitochondrial function in skeletal muscle cells in vitro

HIGHLIGHTS

  • who: Therapeutic vs. and colleagues from the Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of, Faculty of have published the paper: Therapeutic vs. Suprapharmacological Metformin Concentrations: Different Effects on Energy Metabolism and Mitochondrial Function in Skeletal Muscle Cells in vitro, in the Journal: (JOURNAL)
  • how: The authors conducted all experiments in conditions of high (25 mM) and low glucose (5.5 mM) as the authors consider energy substrate availability to be important especially when studying an agent that is believed to alter pathways of glucose metabolism.
  • future: Studying the effects . . .

     

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