HIGHLIGHTS
SUMMARY
Cs is also used as an enhancer of transcellular and paracellular transport of drugs both in_vitro and in_vivo. Within the framework of this study, a variety of physicochemical assays were caried out followed by in_vitro and in_vivo tests. The diffusion rate of 2-PAM through the chitosome membrane was estimated in_vitro by spectrophotometry by varying the Cs concentration and Cs modification. For the first time, in_vivo experiments were carried out to determine the degree of AChE reactivation during intranasal administration of 2-PAM encapsulated in chitosomes. The results obtained were analyzed and compared with . . .
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