Thermo-l-asparaginases: from the role in the viability of thermophiles and hyperthermophiles at high temperatures to a molecular understanding of their thermoactivity and thermostability

HIGHLIGHTS

SUMMARY

Thermophiles and hyperthermophiles are unique microorganisms that not only survive but also thrive at high temperatures. L-ASNase (EC 3.5.1.1; L-asparagine amidohydrolase) catalyzes the conversion of the amino_acid L-asparagine (L-Asn) to L-aspartic acid and ammonia and is used in the pharmaceutical, biosensor and food industries. By catalyzing the hydrolysis of L-Asn, L-ASNase prevents the reaction of reducing_sugars with this amino_acid to form carcinogenic acrylamide. According to the historical classification, L-ASNases are divided into three major groups depending on amino_acid sequence, expressing organism, substrate specificity . . .

 



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