Thermodynamic correlation between liquid-liquid phase separation and crystalline solubility of drug-like molecules

HIGHLIGHTS

  • who: Taiga Uekusa et al. from the Molecular Pharmaceutics Lab, College of Pharmaceutical Sciences, Ritsumeikan University, Noji-higasi, Kusatsu, Shiga, Japan have published the research work: Thermodynamic Correlation between Liquid-Liquid Phase Separation and Crystalline Solubility of Drug-Like Molecules, in the Journal: Pharmaceutics 2022, 14, 2560. of /2022/
  • what: The aim of this study was to experimentally confirm the the intrinsic separation (LLPS) concentration (S0LLPS ) and crystalline solubility (S0c ) of drug-like molecules. Even though this approach has been investigated for more than several decades, S0c prediction is still challenging . The results of this . . .

     

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