These authors contributed equally to this work. received: 25 november 2021 revised: 05 may 2022 accepted: 09 may 2022 accepted manuscript online: 20 may 2022 version of record published: 09 june

HIGHLIGHTS

• who: Bioscience Reports ( et al. from the School Tianjin University have published the paper: These authors contributed equally to this work. Received: 25 November 2021 Revised: 05 May 2022 Accepted: 09 May 2022 Accepted Manuscript online: 20 May 2022 Version of Record published: 09 June, in the Journal: (JOURNAL) of 09/06/2022
• what: The study shows that even a far-upstream component of the iron regulatory machinery (Grx3/4) can be bypassed and cellular networks involving RIM101 pH sensing cAMP signaling mTOR nutritional signaling or bromodomain acetylation may confer the bypassing activities.
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