­the­therapeutic­effect­of­tacrolimus­in­a­mouse­ ­psoriatic­model­is­associated­with­the­induction­of­ myeloid-derived­suppressor­cells

HIGHLIGHTS

• who: Shaokui Chen and colleagues from the State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China have published the paper: u00adTheu00adtherapeuticu00adeffectu00adofu00adtacrolimusu00adinu00adau00admouseu00ad u00adpsoriaticu00admodelu00adisu00adassociatedu00adwithu00adtheu00adinductionu00adofu00ad myeloid-derivedu00adsuppressoru00adcells, in the Journal: (JOURNAL)
• what: This study shows that the antipsoriatic effect of TAC in IMQ-induced mouse psoriasis is TNFR2-depedent.
• how: The results showed that although TAC markedly inhibited skin inflammation in IMQinduced mouse u00adpsoriasis in a TNFR2-dependent manner treatment with TAC failed to increase the number of Tregs. Data were analyzed using FlowJo software . . .
  

   

  

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