Three-component access to functionalized spiropyrrolidine heterocyclic scaffolds and their cholinesterase inhibitory activity

HIGHLIGHTS

  • who: Sarra Boudriga et al. from the Department Chemistry, Laboratory Chemistry Natural Product and Reactivity/CHPNR, Besançon, France have published the article: Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity, in the Journal: Molecules 2020, 1963 of /2020/
  • what: To conclude, we have developed an efficient and practical strategy for the multicomponent 1,3-dipolar cycloaddition of (E)-3-benzylidene-1-phenyl-succinimides, 1,2-cyclic diketones, and diverse α-aminoacids.

SUMMARY

    (2R*,3S*,4R*,5R*)-spir oxindole-spir -N-phenylsuccinimide-4,5-diphenyl-pyrrolidine (4a . . .

     

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