Three-dimensional cancer cell migration directed by dual mechanochemical guidance

HIGHLIGHTS

• who: Pedram Esfahani from the DepartmentState University, Corvallis, Oregon, USA have published the paper: Three-dimensional cancer cell migration directed by dual mechanochemical guidance, in the Journal: (JOURNAL) of 12/04/2022
• what: Addressing the knowledge gap, here the authors report a combined experimental and theoretical analysis to elucidate 3D breast cancer cell motility under joint control of mechanical and chemical cues. The authors show that both ECM microstructure and cell mechanotransduction modulate cancer cell chemotaxis. Because both serum gradient and collagen fiber alignment are primarily in the x-y plane, the authors focus on . . .
  

   

  

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