Three-dimensional chromatin architecture datasets for aging and alzheimer’s disease

HIGHLIGHTS

• who: Guofeng Meng from the InstitutShanghai University have published the paper: Three-dimensional chromatin architecture datasets for aging and Alzheimeru2019s disease, in the Journal: (JOURNAL) of 10/01/2023
• how: The authors used H3K27ac and ATAC-seq signals to define cis-regulatory regions (CREs). The AD GWAS analysis results were collected from a published meta-analysis on PGC-ALZ IGAP ADSP and UKB6-9. For interaction profiles of active regions the authors applied R package InteractionSet to calculate the interaction frequency between active regulatory regions. The authors identified 2704 differentially expressed genes (DEGs) in AD . . .
  

   

  

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