Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids

HIGHLIGHTS

• who: METHODS TECHNIQUES from the Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain tumorThe majority of GBMs form rapidly from normal brain cells, while around, % are secondary to low-grade astrocytomas (Louis et_al, ). Current therapies include surgical removal of the bulk of the tumor, combined with radiation therapy and chemotherapy aimed at killing the remaining cells that have infiltrated the parenchyma. However, despite treatment, GBM usually recurs, contributing to extremely poor patient survival (3-7%) beyond , years (Aldape et_al, ). To advance our understanding of tumor biology and develop new , Wellcome, MRC Cambridge . . .
  

   

  

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