Three stepwise ph progressions in stratum corneum for homeostatic maintenance of the skin

HIGHLIGHTS

• What: With mathematical modeling, the authors demonstrate the controlled protease activation of kallikreinrelated peptidases on the stratum corneum surface that results in proper corneocyte shedding in desquamation. The authors aimed to elucidate the in_vivo SC-pH distribution and biological significance of pH in SC homeostasis. As the skin exhibited grooved wrinkles (Fig 1c) and the confocal microscopic image in the X-Y plane offered higher resolution than the reconstituted Z-sliced section (Fig 1b), the authors focused on the grooved wrinkles in the X-Y plane image (Fig 1c).
• Who: Keitaro Fukuda from the complexThe . . .
  

   

  

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