Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes

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SUMMARY

A thorough analysis of cardiotoxicity of eight TKIs on cardiomyocytes and in patient data At first, an in_vitro human cardiomyocyte-based cell culture system was established to classify TKIs with different levels of cardiotoxicity. Predicting cardiotoxicity of drugs using in_vitro assays remain challenging and researchers try to improve the accuracy of prediction by increasing the number of cell lines or the types of measurements. Afatinib is ranked as highly cardiotoxic based on mitochondrial and beating assays, with little toxicity found in FAERS or literature; this discrepancy could be due to that the dose of . . .

 



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