Thyroid hormone response element organization dictates the composition of active receptor*

HIGHLIGHTS

• who: Lara F.R. Velasco from the (UNIVERSITY) have published the Article: Thyroid Hormone Response Element Organization Dictates the Composition of Active Receptor*, in the Journal: (JOURNAL) of April/27,/2007
• what: The authors compare actions of wild_type and mutant TRs at different TREs in yeast and in mammalian cells. The authors propose that TRE half-site orientation dictates the composition of the active form of TR in_vivo and that this effect should be considered in analysis of TR activity and design of selective TR modulators. Because RXR-TR heterodimers are active at DR-4 . . .
  

   

  

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