Thz1 targeting cdk7 suppresses stat transcriptional activity and sensitizes t-cell lymphomas to bcl2 inhibitors

HIGHLIGHTS

• who: Florencia Cayrol from the Molecular Oncology Department, Institute for Biomedical Research (BIOMED), National Research Council of Argentina (CONICET), Catholic University of have published the article: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 30/01/2017
• what: The authors report that PTCL are sensitive to transcription-targeting drugs and in particular to a covalent inhibitor of cyclin-dependent kinase 7 (CDK7). The authors report that inhibitors of the proteasome, RNA_polymerase II (RNA POL2)-mediated transcription and lysine deacetylases (KDAC . . .
  

   

  

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