Tim-3 expression on dendritic cells in colorectal cancer

HIGHLIGHTS

• What: The authors investigated the expression of TIM-3 using transcriptomic data from a public database and immunohistochemical (IHC) evaluations from the cohorts of CRC and also examined the expression of TIM-3 and its related molecules, cGAS and STING, on immature and mature DCs in_vitro. The authors analyzed the mRNA expression levels of TIM-3 (HAVCR2), DC-SIGN (CD209), and CD83 (CD83). This study was approved by the Ethical Committee of Fukushima Medical University (Reference No 2289), and all patients provided written informed consent before enrollment. The authors showed that DCs highly expressing TIM-3 were . . .
  

   

  

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