Time of day and length of antidepressant drug administration influence brain-derived neurotrophic factor and trkb levels in rat brain

HIGHLIGHTS

  • who: Test from the Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA have published the article: Time of Day and Length of Antidepressant Drug Administration Influence Brain-Derived Neurotrophic Factor and TrkB Levels in Rat Brain, in the Journal: (JOURNAL)
  • what: We observed a down-regulation of BDNF mRNA levels after acute DMI (10 mg/kg/injection, twice daily) 12-14 hours post drug in the hippocampus similar to what others have also reported [21, 25, 26].
  • how: Pollock and colleagues have demonstrated that BDNF protein circadian . . .

     

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