Tissue plasminogen activator mediates microglial activation via its finger domain through annexin ii

HIGHLIGHTS

• who: / and colleagues from the DepartmentUniversity Medical have published the research work: Tissue Plasminogen Activator Mediates Microglial Activation via Its Finger Domain through Annexin II, in the Journal: (JOURNAL)
• what: The authors show here in culture studies that stimulated wild-type neurons and microglia can release the tPA that elicits the activation and that tPA acts in combination with other factors. The authors show that microglial activation can further stimulate release of microglial factors, such as tPA, that can in turn activate neighboring microglia in an autocrine or paracrine manner. It is widely accepted that . . .
  

   

  

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