Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cdc1-cd8 t activity

HIGHLIGHTS

• What: The authors demonstrate how inducing localized physical damage using ionizing radiation (IR) unmasks the benefit of immunotherapy by increasing tissue-resident NK (trNK) cells that support CD8 T activity. The authors show an equivalent population in human PDAC cohorts that represents an adaptive-like immunomodulatory trNK-cell that similarly supports CD8 T cell levels in a cDC1-dependent manner. The authors focused on UMAP projections of the CD8 and NK compartment alone to reveal three clear NK subpopulations that are distinct from CD8 T_cells and clearly separate out in clusters of immature (NK_C3), active (NK_C2) and . . .
  

   

  

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