Tissue-specific sex differences in pediatric and adult immune cell composition and function

HIGHLIGHTS

• What: Given that LAIV induced the strongest response (i.e. increase in plasmablast frequency) of the antigens tested (Supplementary Figure 3A), the authors focused the majority of subsequent analyses of sex-based differences on this vaccine format. The authors evaluated sex differences in the immune cell composition of human tonsils and assessed the humoral and cellular immune_responses to LAIV and IIV using a human tonsil organoid platform. The study provides new data to explain sex differences in the human adaptive immune_response from a lymphoid tissue perspective and supports a model for the consideration of age and sex . . .
  

   

  

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