Title neuroendocrine markers inversely correlate with yap1 and wwtr1 expression in merkel cell carcinoma

HIGHLIGHTS

  • who: Gartin and Ashley from the Program in Virology, Graduate School Arts and Sciences, Harvard University, Cambridge, MA, USA have published the article: Title Neuroendocrine markers inversely correlate with YAP1 and WWTR1 expression in Merkel cell carcinoma, in the Journal: (JOURNAL)
  • what: The authors show that expression of YAP1 or WWTR1 in a NE-hi MCCP cell line can reduce cell viability and induce a cell-cycle arrest at least in part through TEAD-dependent transcriptional suppression of MCPyV LT. Given the ability of YAP1 and WWTR1 to repress MCPyV T antigen expression, the authors . . .

     

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